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T15635 |
JZP-430
|
|
Lipase
,
MAGL
|
|
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL... |
|
T15614 |
JJKK 048
|
|
Lipase
|
|
JJKK 048 is a potent and selective MAGL inhibitor. |
|
T8974 |
ML-211
|
|
Others
|
|
ML-211 is a carbamate-based dual inhibitor of LYPLA1 (IC50 = 17 nM) and the related LYPLA2 (IC50 = 30 nM) |
|
T9687 |
MAGL-IN-4
|
His121 ARG57 |
Lipase
|
|
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases. |
|
T9967 |
MAGL-IN-5
|
|
Lipid
|
|
MAGL-IN-5 is a non-selective lipase inhibitor. |
|
T5353 |
ABX-1431
|
Elcubragistat |
Lipase
|
|
ABX-1431 (Elcubragistat) is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM). |
|
T15632 |
JW 642
|
|
Lipase
|
|
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, respectively). |
|
T17260 |
WWL70
|
|
Lipase
,
MAGL
|
|
WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM). |
|
T61294 |
Monoacylglycerol lipase inhibitor 1
|
|
|
|
Monoacylglycerol lipase inhibitor 1, also known as compound 13 [1], is a potent inhibitor of monoacylglycerol lipase. |
|
T4052 |
KML29
|
|
Lipase
|
|
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effective... |
|
T5815 |
MJN110
|
Cravatt Reagent |
Lipase
|
|
MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing Effects in a Mouse Neuropathic Pain Model. |
|
T2338 |
JZL195
|
|
FAAH
,
Lipase
,
Autophagy
|
|
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor. |
|
T6554 |
JZL 184
|
JZL184 |
Lipase
|
|
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively. |
|
T8994 |
ML-226
|
ML226,ML-226 |
MAGL
|
|
ML226 is a α/β hydrolase domain-containing protein 11 (ABHD11) inhibitor that inhibits ABHD11 in vitro and in situ. |
|
T9374 |
AA38-3
|
1-Piperidinecarboxylic acid, 4-nitrophenyl ester |
FAAH
,
Lipase
,
MAGL
|
|
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH) |
|
T27405 |
GAT211
|
GAT-211,AZ-4,GAT 211,AZ 4,AZ4 |
|
|
GAT211 is a CB1 positive allosteric modulator. GAT211 suppresses allodynia and produces synergistic antiallodynic effects with monoacylglycerol lipase and fatty acid amide hydrolase inhibitors in paclitaxel-treated mice. |
|
T3591 |
URB602
|
|
Lipase
,
Antibacterial
|
|
URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism. |
|
T11724 |
JNJ-42226314
|
|
Lipase
|
|
JNJ-42226314 is a highly selective non-covalent monoacylglycerol lipase (MAGL) inhibitor with anti-injury effects.JNJ-42226314 shows efficacy via endogenous cannabinoid-2-acryloylglycerol (2-AG) in models of neuropathic ... |
|
T28165 |
NF-1819
|
NF 1819,NF1819 |
Lipase
|
|
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model ... |
|
T71493 |
AM6580
|
|
|
|
AM6580 is an irreversible monoacylglycerol lipase (MGL) inhibitor. |
|
T11939 |
MAGL-IN-1
|
|
Lipase
|
|
MAGL-IN-1 is a selective and potent monoacylglycerol lipase (MAGL) inhibitor with an IC50 of 80 nM. |
|
T27811 |
LEI-106
|
|
|
|
LEI-106, a novel potent sn-1 DAGLalpha inhibitor, blocks the hydrolysis of sn-1-oleoyl-2-AG, inhibits the hydrolysis of 2-AG by the monoacylglycerol lipase ABHD6. |
|
T36498 |
CAY10762
|
CAY10762 |
|
|
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC50= 34.1 nM).1It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg... |
|
T21905 |
N-Arachidonyl Maleimide
|
|
|
|
N-Arachidonyl maleimide is a potent, irreversible monoacylglycerol lipase (MAGL) inhibitor with an IC 50 value of 140 nM [1]. |
|
T81880 |
MAGL-IN-11
|
|
MAGL
|
|
MAGL-IN-11 (compound 29) is a selective, reversible inhibitor of monoacylglycerol lipase (MAGL), with potential in researching inflammation, cancer, and antioxidants [1]. |
|
T81878 |
MAGL-IN-9
|
|
MAGL
|
|
MAGL-IN-9, also referred to as compound 16, is a reversible inhibitor of monoacylglycerol lipase (MAGL) with a potent IC50 value of 2.7 nM [1]. |
|
T81879 |
MAGL-IN-8
|
|
MAGL
|
|
MAGL-IN-8 (compound 13) serves as a reversible inhibitor of monoacylglycerol lipase (MAGL), exhibiting an inhibitory concentration half-maximal (IC50) value of 2.5 ± 0.4 nM for human MAGL (hMAGL) [1]. |
|
T61198 |
FAAH/MAGL-IN-1
|
|
|
|
FAAH/MAGL-IN-1, also known as compound SIH 3, is a highly effective inhibitor of FAAH (fatty acid amide hydrolase) and MAGL (monoacylglycerol lipase). It exhibits IC50 values of 31 nM and 29 nM against FAAH and MAGL, res... |
|
T81881 |
MAGL-IN-10
|
|
MAGL
|
|
MAGL-IN-10, a reversible monoacylglycerol lipase (MAGL) inhibitor, exhibits favorable ADME properties and low in vivo toxicity. It is applicable in the study of cancer, neurological disorders, and inflammatory pathologie... |
|
T35786 |
O-7460
|
|
|
|
In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol by attacking DAG at the sn-1 position. O-7460 is a selective inhibitor of 2-AG biosynthesis via DAGLα (... |
|
T62671 |
FAAH/MAGL-IN-3
|
|
|
|
FAAH/MAGL-IN-3 (Compound 10) is an irreversible dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) that acts on FAAH (IC50: 179 nM) and MAGL (IC50: 759 nM). FAAH/MAGL-IN-3 showed littl... |
|
T73317 |
JZP-MA-13
|
|
|
|
JZP-MA-13 is a selective α/β-hydrolase domain 6 (ABHD6) inhibitor, demonstrating impressive specificity with an IC50 value of 392 nM, and exhibits no inhibitory effects on monoacylglycerol lipase (MAGL), ABHD12, fatty ac... |
|
T37629 |
IDFP
|
|
|
|
The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors,... |
|
T37374 |
URB754
|
|
|
|
URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mo... |
